Mother and Baby Communication During Early Pregnancy, the Key to Establishing a Healthy Pregnancy

EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia

CL Whitehead, TJ Kaitu'u-Lino, NK Binder, S Beard, N De Alwis, F Brownfoot, S Tong, NJ Hannan

2018-10-01

Introduction: Preeclampsia is a severe complication of pregnancy, and likely arises from abnormal placental development in early p..

Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction

NJ Hannan, S Beard, NK Binder, K Onda, TJ Kaitu'u-Lino, Q Chen, L Tuohey, M De Silva, S Tong

2017-03-01

Introduction Preeclampsia (PE) and fetal growth restriction (FGR) are among the leading causes of perinatal morbidity and mortalit..

Placental growth factor is secreted by the human endometrium and has potential important functions during embryo development and implantation

NK Binder, J Evans, LA Salamonsen, DK Gardner, TJ Kaitu'u-Lino, NJ Hannan

2016-10-01

Embryo implantation requires synchronized dialogue between the receptive endometrium and activated blastocyst via locally produced..

Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic Activity

KR Palmer, TJ Kaitu'u-Lino, R Hastie, NJ Hannan, L Ye, N Binder, P Cannon, L Tuohey, TG Johns, A Shub, S Tong

2015-12-01

In preeclampsia, the antiangiogenic factor soluble fms-like tyrosine kinase-1 (sFLT-1) is released from placenta into the maternal..

Heme oxygenase-1 is not decreased in preeclamptic placenta and does not negatively regulate placental soluble fms-like tyrosine kinase-1 or soluble endoglin secretion

S Tong, TJ Kaitu'u-Lino, K Onda, S Beard, R Hastie, NK Binder, C Cluver, L Tuohey, C Whitehead, F Brownfoot, M De Silva, NJ Hannan

2015-11-01

Elevated placental release of the antiangiogenic factors, soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG),..

Effects of Pravastatin on Human Placenta, Endothelium, and Women with Severe Preeclampsia

FC Brownfoot, S Tong, NJ Hannan, NK Binder, SP Walker, P Cannon, R Hastie, K Onda, TJ Kaitu'U-Lino

2015-09-14

Preeclampsia is a major pregnancy complication where excess placental release of soluble fms-like tyrosine kinase-1 (sFlt-1) and s..

YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia

FC Brownfoot, S Tong, NJ Hannan, R Hastie, P Cannon, L Tuohey, TJ Kaitu'u-Lino

2015-09-05

Preeclampsia is a serious complication of pregnancy with no medical treatment. It is caused by intermittent placental hypoxia and ..

Invitro embryo outgrowth is a bioassay of invivo embryo implantation and development

NK Binder, NJ Hannan, DK Gardner

2015-09-01

Objective: To determine the efficacy of embryo outgrowth on fibronectin as a low cost, high throughput alternative to embryo trans..

Transcription factors E2F1 and E2F3 are expressed in placenta but do not regulate MMP14

TJ Kaitu'u-Lino, R Hastie, P Cannon, H Nguyen, S Lee, NJ Hannan, S Tong

2015-08-01

Introduction Preeclampsia is a serious complication of pregnancy for which there are no efficacious medical treatments. Soluble en..

Chorioamnionitis occurring in women with preterm rupture of the fetal membranes is associated with a dynamic increase in mRNAs coding cytokines in the maternal circulation

O Stock, L Gordon, J Kapoor, SP Walker, C Whitehead, TJ Kaitu'U-Lino, G Pell, NJ Hannan, S Tong

2015-07-03

Background: Preterm prelabor rupture of the fetal membranes (PPROM) is a significant contributor to the morbidity and mortality of..

Low female birth weight and advanced maternal age programme alterations in next-generation blastocyst development

JS Master, GA Thouas, AJ Harvey, JR Sheedy, NJ Hannan, DK Gardner, ME Wlodek

2015-05-01

Low birth weight is associated with an increased risk for adult disease development with recent studies highlighting transmission ..

Paternal obesity in a rodent model affects placental gene expression in a sex-specific manner

NK Binder, SA Beard, TJ Kaitu'U-Lino, S Tong, NJ Hannan, DK Gardner

2015-05-01

Fetal growth restriction (FGR) is a major obstetric complication stemming from poor placental development. We have previously demo..

Sofalcone upregulates the nuclear factor (Erythroid-Derived 2)-Like 2/Heme Oxygenase-1 Pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: Potential therapeutic for preeclampsia

K Onda, S Tong, A Nakahara, M Kondo, H Monchusho, T Hirano, T Kaitu'u-Lino, S Beard, N Binder, L Tuohey, F Brownfoot, NJ Hannan

2015-04-20

Preeclampsia is a severe complication of pregnancy, characterized by hypertension, oxidative stress, and severe endothelial dysfun..

Endometrial signals improve embryo outcome: Functional role of vascular endothelial growth factor isoforms on embryo development and implantation in mice

NK Binder, J Evans, DK Gardner, LA Salamonsen, NJ Hannan

2014-10-10

STUDY QUESTION: Does vascular endothelial growth factor (VEGF) have important roles during early embryo development and implantati..

Characterization of protocols for primary trophoblast purification, optimized for functional investigation of sFlt-1 and soluble endoglin

TJ Kaitu'U-Lino, S Tong, S Beard, R Hastie, L Tuohey, F Brownfoot, K Onda, NJ Hannan

2014-10-01

Objectives Soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng) are the most studied molecules in preeclampsia...

Peptides do not prevent cleavage of endoglin to produce soluble endoglin

R Hastie, S Tong, P Cannon, F Brownfoot, NJ Hannan, T Kaitu'U-Lino

2014-10-01

MMP14 cleaves membrane bound endoglin to produce soluble endoglin (sEng), an anti-angiogenic factor that causes endothelial dysfun..

Male obesity is associated with changed spermatozoa Cox4i1 mRNA level and altered seminal vesicle fluid composition in a mouse model

NK Binder, JR Sheedy, NJ Hannan, DK Gardner

2014-07-21

The rate of obesity among men of reproductive age has tripled in the last three decades. Previously, we demonstrated that paternal..

A bioplex analysis of cytokines and chemokines in first trimester maternal plasma to screen for predictors of miscarriage

NJ Hannan, K Bambang, TJ Kaitu'u-Lino, JC Konje, S Tong

2014-04-03

Background: We have previously shown in two independent cohorts that circulating first trimester Macrophage Inhibitory Cytokine-1 ..

Placental SEMA3B expression is not altered in severe early onset preeclampsia

TJ Kaitu'u-Lino, R Hastie, P Cannon, NK Binder, S Lee, O Stock, NJ Hannan, S Tong

2014-01-01

Recent evidence suggests that Semaphorin 3B (SEMA3B) is upregulated in severe preeclampsia, and a major driver of cytotrophoblast ..

Stability of absolute copy number of housekeeping genes in preeclamptic and normal placentas, as measured by digital PCR

TJ Kaitu'u-Lino, R Hastie, P Cannon, S Lee, O Stock, NJ Hannan, R Hiscock, S Tong

2014-01-01

Measuring mRNA expression is fundamental to placental research. Ideally, mRNA transcript numbers are directly quantified. However,..

Proteomics of the human endometrium and uterine fluid: A pathway to biomarker discovery

LA Salamonsen, T Edgell, LJF Rombauts, AN Stephens, DM Robertson, A Rainczuk, G Nie, NJ Hannan

2013-03-15

Failure of the endometrium to achieve receptivity results in infertility, and it is also a rate-limiting step in in vitro fertiliz..

Defective Soil for a Fertile Seed? Altered Endometrial Development Is Detrimental to Pregnancy Success

J Evans, NJ Hannan, C Hincks, LJF Rombauts, LA Salamonsen

2012-12-31

Background: Synchronous development of the endometrium (to achieve a receptive state) and of the embryo is essential for successfu..

Paternal Diet-Induced Obesity Retards Early Mouse Embryo Development, Mitochondrial Activity and Pregnancy Health

NK Binder, NJ Hannan, DK Gardner

2012-12-27

Worldwide, 48% of adult males are overweight or obese. An association between infertility and excessive body weight is now accepte..

Uterine lavage or aspirate: Which view of the intrauterine environment?

NJ Hannan, G Nie, A Rainzcuk, LJF Rombauts, LA Salamonsen

2012-10-01

Fluid within the uterine cavity provides the microenvironment for preimplantation blastocyst development and early implantation. A..

Analysis of fertility-related soluble mediators in human uterine fluid identifies VEGF as a key regulator of embryo implantation

NJ Hannan, P Paiva, KL Meehan, LJF Rombauts, DK Gardner, LA Salamonsen

2011-12-01

Embryo implantation requires synchronized dialogue between the receptive endometrium and activated blastocyst via locally produced..

Alternate roles for immune regulators: Establishing endometrial receptivity for implantation

NJ Hannan, J Evans, LA Salamonsen

2011-11-01

Many immune regulators are now identified as having key roles at the embryo-maternal interface. Importantly, a cohort of cytokines..