Grant number: 628927 | Funding period: 2010 - 2015
Completed
CL Whitehead, TJ Kaitu'u-Lino, NK Binder, S Beard, N De Alwis, F Brownfoot, S Tong, NJ Hannan
2018-10-01
Introduction: Preeclampsia is a severe complication of pregnancy, and likely arises from abnormal placental development in early p..
NJ Hannan, S Beard, NK Binder, K Onda, TJ Kaitu'u-Lino, Q Chen, L Tuohey, M De Silva, S Tong
2017-03-01
Introduction Preeclampsia (PE) and fetal growth restriction (FGR) are among the leading causes of perinatal morbidity and mortalit..
NK Binder, J Evans, LA Salamonsen, DK Gardner, TJ Kaitu'u-Lino, NJ Hannan
2016-10-01
Embryo implantation requires synchronized dialogue between the receptive endometrium and activated blastocyst via locally produced..
KR Palmer, TJ Kaitu'u-Lino, R Hastie, NJ Hannan, L Ye, N Binder, P Cannon, L Tuohey, TG Johns, A Shub, S Tong
2015-12-01
In preeclampsia, the antiangiogenic factor soluble fms-like tyrosine kinase-1 (sFLT-1) is released from placenta into the maternal..
S Tong, TJ Kaitu'u-Lino, K Onda, S Beard, R Hastie, NK Binder, C Cluver, L Tuohey, C Whitehead, F Brownfoot, M De Silva, NJ Hannan
2015-11-01
Elevated placental release of the antiangiogenic factors, soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG),..
FC Brownfoot, S Tong, NJ Hannan, NK Binder, SP Walker, P Cannon, R Hastie, K Onda, TJ Kaitu'U-Lino
2015-09-14
Preeclampsia is a major pregnancy complication where excess placental release of soluble fms-like tyrosine kinase-1 (sFlt-1) and s..
FC Brownfoot, S Tong, NJ Hannan, R Hastie, P Cannon, L Tuohey, TJ Kaitu'u-Lino
2015-09-05
Preeclampsia is a serious complication of pregnancy with no medical treatment. It is caused by intermittent placental hypoxia and ..
NK Binder, NJ Hannan, DK Gardner
2015-09-01
Objective: To determine the efficacy of embryo outgrowth on fibronectin as a low cost, high throughput alternative to embryo trans..
TJ Kaitu'u-Lino, R Hastie, P Cannon, H Nguyen, S Lee, NJ Hannan, S Tong
2015-08-01
Introduction Preeclampsia is a serious complication of pregnancy for which there are no efficacious medical treatments. Soluble en..
O Stock, L Gordon, J Kapoor, SP Walker, C Whitehead, TJ Kaitu'U-Lino, G Pell, NJ Hannan, S Tong
2015-07-03
Background: Preterm prelabor rupture of the fetal membranes (PPROM) is a significant contributor to the morbidity and mortality of..
JS Master, GA Thouas, AJ Harvey, JR Sheedy, NJ Hannan, DK Gardner, ME Wlodek
2015-05-01
Low birth weight is associated with an increased risk for adult disease development with recent studies highlighting transmission ..
NK Binder, SA Beard, TJ Kaitu'U-Lino, S Tong, NJ Hannan, DK Gardner
Fetal growth restriction (FGR) is a major obstetric complication stemming from poor placental development. We have previously demo..
K Onda, S Tong, A Nakahara, M Kondo, H Monchusho, T Hirano, T Kaitu'u-Lino, S Beard, N Binder, L Tuohey, F Brownfoot, NJ Hannan
2015-04-20
Preeclampsia is a severe complication of pregnancy, characterized by hypertension, oxidative stress, and severe endothelial dysfun..
NK Binder, J Evans, DK Gardner, LA Salamonsen, NJ Hannan
2014-10-10
STUDY QUESTION: Does vascular endothelial growth factor (VEGF) have important roles during early embryo development and implantati..
TJ Kaitu'U-Lino, S Tong, S Beard, R Hastie, L Tuohey, F Brownfoot, K Onda, NJ Hannan
2014-10-01
Objectives Soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng) are the most studied molecules in preeclampsia...
R Hastie, S Tong, P Cannon, F Brownfoot, NJ Hannan, T Kaitu'U-Lino
MMP14 cleaves membrane bound endoglin to produce soluble endoglin (sEng), an anti-angiogenic factor that causes endothelial dysfun..
NK Binder, JR Sheedy, NJ Hannan, DK Gardner
2014-07-21
The rate of obesity among men of reproductive age has tripled in the last three decades. Previously, we demonstrated that paternal..
NJ Hannan, K Bambang, TJ Kaitu'u-Lino, JC Konje, S Tong
2014-04-03
Background: We have previously shown in two independent cohorts that circulating first trimester Macrophage Inhibitory Cytokine-1 ..
TJ Kaitu'u-Lino, R Hastie, P Cannon, NK Binder, S Lee, O Stock, NJ Hannan, S Tong
2014-01-01
Recent evidence suggests that Semaphorin 3B (SEMA3B) is upregulated in severe preeclampsia, and a major driver of cytotrophoblast ..
TJ Kaitu'u-Lino, R Hastie, P Cannon, S Lee, O Stock, NJ Hannan, R Hiscock, S Tong
Measuring mRNA expression is fundamental to placental research. Ideally, mRNA transcript numbers are directly quantified. However,..
LA Salamonsen, T Edgell, LJF Rombauts, AN Stephens, DM Robertson, A Rainczuk, G Nie, NJ Hannan
2013-03-15
Failure of the endometrium to achieve receptivity results in infertility, and it is also a rate-limiting step in in vitro fertiliz..
J Evans, NJ Hannan, C Hincks, LJF Rombauts, LA Salamonsen
2012-12-31
Background: Synchronous development of the endometrium (to achieve a receptive state) and of the embryo is essential for successfu..
2012-12-27
Worldwide, 48% of adult males are overweight or obese. An association between infertility and excessive body weight is now accepte..
NJ Hannan, G Nie, A Rainzcuk, LJF Rombauts, LA Salamonsen
2012-10-01
Fluid within the uterine cavity provides the microenvironment for preimplantation blastocyst development and early implantation. A..
NJ Hannan, P Paiva, KL Meehan, LJF Rombauts, DK Gardner, LA Salamonsen
2011-12-01
NJ Hannan, J Evans, LA Salamonsen
2011-11-01
Many immune regulators are now identified as having key roles at the embryo-maternal interface. Importantly, a cohort of cytokines..